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Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by constructions-dependent virtual screening As well as in vitro bioassays
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The crystal buildings in the MIF-inhibitor complexes were being utilised since the Original templates for Digital screening. The Protein Preparation Wizard module in Schrödinger was utilised to organize Each individual MIF advanced. The ligand positioned from the Energetic web site among chains A and B was maintained. The complicated was then refined with the OPLS power area [26]. Pro1, an important nucleophilic residue, was protonated In keeping with experimental and theoretical results [27].
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